CIG-DB: the database for human or mouse immunoglobulin and T cell receptor genes available for cancer studies

Background: Immunoglobulin (IG or antibody) and the T-cell receptor (TR) are pivotal proteins in the immune system of higher organisms. In cancer immunotherapy, the immune responses mediated by tumor-epitope-binding IG or TR play important roles in anticancer effects. Although there are public databases specific for immunological genes, their contents have not been associated with clinical studies. Therefore, we developed an integrated database of IG/TR data reported in cancer studies (the Cancer-related Immunological Gene Database [CIG-DB]). Description: This database is designed as a platform to explore public human and murine IG/TR genes sequenced in cancer studies. A total of 38,308 annotation entries for IG/TR proteins were collected from GenBank/DDBJ/EMBL and the Protein Data Bank, and 2,740 non-redundant corresponding MEDLINE references were appended. Next, we the MEDLINE texts by MeSH terms, titles, and abstracts containing keywords related to cancer. After we performed a manu...

• Type: Journal
• Year: 2010
• Where: BMCBI
• Authors: Yoji Nakamura, Tomoyoshi Komiyama, Motoki Furue, Takashi Gojobori, Yasuto Akiyama
• Keywords: BMCBI 2010, Cancer Studies, Database, Immunological Gene