The Neural/Immune Gene Ontology: clipping the Gene Ontology for neurological and immunological systems

Background: The Gene Ontology (GO) is used to describe genes and gene products from many organisms. When used for functional annotation of microarray data, GO is often slimmed by editing so that only higher level terms remain. This practice is designed to improve the summarizing of experimental results by grouping high level terms and the statistical power of GO term enrichment analysis. Here, we propose a new approach to editing the gene ontology, clipping, which is the editing of GO according to biological relevance. Creation of a GO subset by clipping is achieved by removing terms (from all hierarchal levels) if they are not functionally relevant to a given domain of interest. Terms that are located in levels higher to relevant terms are kept, thus, biologically irrelevant terms are only removed if they are not parental to terms that are relevant. Results: Using this approach, we have created the Neural-Immune Gene Ontology (NIGO) subset of GO directed for neurological and immunolo...

• Type: Journal
• Year: 2010
• Where: BMCBI
• Authors: Nophar Geifman, Alon Monsonego, Eitan Rubin
• Keywords: BMCBI 2010, Gene Ontology, Level Terms, Relevant Terms