Optimizing structural modeling for a specific protein scaffold: knottins or inhibitor cystine knots

Background: Knottins are small, diverse and stable proteins with important drug design potential. They can be classified in 30 families which cover a wide range of sequences (1621 sequenced), three-dimensional structures (155 solved) and functions (> 10). Inter knottin similarity lies mainly between 15% and 40% sequence identity and

• Type: Journal
• Year: 2010
• Where: BMCBI
• Authors: Jérôme Gracy, Laurent Chiche
• Keywords: BMCBI 2010, Important Drug Design, Inter Knottin Similarity, Three-dimensional Structures