Compartmentalization of the Edinburgh Human Metabolic Network

Background: Direct in vivo investigation of human metabolism is complicated by the distinct metabolic functions of various sub-cellular organelles. Diverse micro-environments in different organelles may lead to distinct functions of the same protein and the use of different enzymes for the same metabolic reaction. To better understand the complexity in the human metabolism, a compartmentalized human metabolic network with integrated sub-cellular location information is required. Results: We extended the previously reconstructed Edinburgh Human Metabolic Network (EHMN) [Ma, et al. Molecular Systems Biology, 3:135, 2007] by integrating the sub-cellular location information for the reactions, adding transport reactions and refining the protein-reaction relationships based on the location information. Firstly, protein location information was obtained from Gene Ontology and complemented by a Swiss-Prot location keywords search. Then all the reactions in EHMN were assigned to a location ba...

• Type: Journal
• Year: 2010
• Where: BMCBI
• Authors: Tong Hao, Hongwu Ma, Xue-Ming Zhao, Igor Goryanin
• Keywords: BMCBI 2010, Human Metabolic Network, Location Information, Sub-cellular Location Information