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CCE
2008

Identification of regulatory mechanisms of the hepatic response to thermal injury

13 years 11 months ago
Identification of regulatory mechanisms of the hepatic response to thermal injury
The purpose of this paper is to evaluate the hypothesis that a systems biology approach can be developed such that a set of transcription factors, relevant to burn-induced inflammatory response can be identified and modulated to control the host response. We explore a novel method for identifying coherent and informative expression motifs and we subsequently determine conserved transcription factor binding sites for the sub-sets of co-expressed genes. The responses are rationalized in the context of burn-induced inflammation and the putative transcription factors are rationalized in the context of intervention targets for controlling gene expression.
Eric Yang, Timothy Maguire, Martin L. Yarmush, Fra
Added 09 Dec 2010
Updated 09 Dec 2010
Type Journal
Year 2008
Where CCE
Authors Eric Yang, Timothy Maguire, Martin L. Yarmush, Francois Berthiaume, Francois P. Androulakis
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