Scalable, Time-Responsive, Digital, Energy-Efficient Molecular Circuits using DNA Strand Displacement

We propose a novel theoretical biomolecular design to implement any Boolean circuit using the mechanism of DNA strand displacement. The design is scalable: all species of DNA strands can in principle be mixed and prepared in a single test tube, rather than requiring separate purification of each species, which is a barrier to large-scale synthesis. The design is timeresponsive: the concentration of output species changes in response to the concentration of input species, so that time-varying inputs may be continuously processed. The design is digital: Boolean values of wires in the circuit are represented as high or low concentrations of certain species, and we show how to construct a single-input, single-output signal restoration gate that amplifies the difference between high and low, which can be distributed to each wire in the circuit ome signal degradation. This means we can achieve a digital abstraction of the analog values of concentrations. Finally, the design is energy-effici...

• Type: Journal
• Year: 2010
• Where: CORR
• Authors: Ehsan Chiniforooshan, David Doty, Lila Kari, Shinnosuke Seki
• Keywords: CORR 2010, Design, DNA Strands, Education, Input Species