This paper presents a real-time vision-based system to assist a person with dementia wash their hands. The system uses only video inputs, and assistance is given as either verbal or visual prompts, or through the enlistment of a human caregiver's help. The system combines a Bayesian sequential estimation framework for tracking hands and towel, with a decision theoretic framework for computing policies of action. The decision making system is a partially observable Markov decision process, or POMDP. Decision policies dictating system actions are computed in the POMDP using a point-based approximate solution technique. The tracking and decision making systems are coupled using a heuristic method for temporally segmenting the input video stream based on the continuity of the belief state. A key element of the system is the ability to estimate and adapt to user psychological states, such as awareness and responsiveness. We evaluate the system in three ways. First, we evaluate the han...