The Health Sciences provide a lively niche for case based reasoning applications. The main justification for this is that case based reasoning is a unique methodology in artificial intelligence, which capitalizes on previous experiences, or cases, for solving new problems. Therefore it is particularly well adapted to life and natural sciences such as biology and medicine, where cases abound. This article summarizes the methodology of case based reasoning, the history of case based reasoning in biomedicine, and introduces the paper assem1