We consider in this paper a new lagrangean relaxation with clusters for the Manufacturer’s Pallet Loading Problem (MPLP). The relaxation is based on the MPLP formulated as a Maximum Independent Set Problem (MISP) and represented in a conflict graph that can be partitioned in clusters. The edges inter clusters are relaxed in a lagrangean fashion. Computational tests attain the optimality for some instances considered difficult for a lagrangean relaxation. Our results show that this relaxation can be a successful approach for hard combinatorial problems modeled in conflict graphs. Moreover, we propose a column generation approach for the MPLP derived from the idea behind the lagrangean relaxation proposed.