On the inapproximability of the exemplar conserved interval distance problem of genomes

In this paper we present two main results about the inapproximability of the exemplar conserved interval distance problem of genomes. First, we prove that it is NP-complete to decide whether the exemplar conserved interval distance between any two genomes is zero or not. This result implies that the exemplar conserved interval distance problem does not admit any approximation in polynomial time, unless P = NP. In fact, this result holds, even when every gene appears in each of the given genomes at most three times. Second, we strengthen the first result under a weaker definition of approximation, called weak approximation. We show that the exemplar conserved interval distance problem does not admit any weak approximation within a super-linear factor of 2

• Type: Journal
• Year: 2008
• Where: JCO
• Authors: Zhixiang Chen, Richard H. Fowler, Bin Fu, Binhai Zhu
• Keywords: Exemplar, Genomes, Interval Distance Problem, JCO 2008