From genomics to chemical genomics: new developments in KEGG

The increasing amount of genomic and molecular information is the basis for understanding higherorder biological systems, such as the cell and the 15 organism, and their interactions with the environment, as well as for medical, industrial and other practical applications. The KEGG resource (http:// www.genome.jp/kegg/) provides a reference knowledge base for linking genomes to biological systems, 20 categorized as building blocks in the genomic space (KEGG GENES) and the chemical space (KEGG LIGAND), and wiring diagrams of interaction networks and reaction networks (KEGG PATHWAY). A fourth component, KEGG BRITE, has been formally 25 added to the KEGG suite of databases. This reflects our attempt to computerize functional interpretations as part of the pathway reconstruction process based on the hierarchically structured knowledge about the genomic, chemical and network spaces. In accord30 ance with the new chemical genomics initiatives, the scope of KEGG LIGAND has been significantly...

• Type: Journal
• Year: 2006
• Where: NAR
• Authors: Minoru Kanehisa, Susumu Goto, Masahiro Hattori, Kiyoko F. Aoki-Kinoshita, Masumi Itoh, Shuichi Kawashima, Toshiaki Katayama, Michihiro Araki, Mika Hirakawa
• Keywords: Biological Systems, KEGG, KEGG LIGAND, NAR 2006