Semantic-based image retrieval has attracted great interest in recent years. This paper proposes a region-based image retrieval system with high-level semantic learning. The key features of the system are: (1) it supports both query by keyword and query by region of interest. The system segments an image into different regions and extracts low-level features of each region. From these features, high-level concepts are obtained using a proposed decision tree-based learning algorithm named DT-ST. During retrieval, a set of images whose semantic concept matches the query is returned. Experiments on a standard real-world image database confirm that the proposed system significantly improves the retrieval performance, compared with a conventional content-based image retrieval system. (2) The proposed decision tree induction method DT-ST for image semantic learning is different from other decision tree induction algorithms in that it makes use of the semantic templates to discretize continu...