Prototype selection problem consists of reducing the size of databases by removing samples that are considered noisy or not influential on nearest neighbour classification tasks. Evolutionary algorithms have been used recently for prototype selection showing good results. However, due to the complexity of this problem when the size of the databases increases, the behaviour of evolutionary algorithms could deteriorate considerably because of a lack of convergence. This additional problem is known as the scaling up problem. Memetic algorithms are approaches for heuristic searches in optimization problems that combine a population-based algorithm with a local search. In this paper, we propose a model of memetic algorithm that incorporates an ad hoc local search specifically designed for optimizing the properties of prototype selection problem with the aim of tackling the scaling up problem. In order to check its performance, we have carried out an empirical study including a comparison b...