Simulation and parameter estimation of dynamics of synaptic depression

Abstract. Synaptic release was simulated using a Simulink sequential storage model with three vesicular pools. Modeling was modular and easily extendable to the systems with greater number of vesicular pools, parallel input, or time-varying parameters. Given an input (short or long tetanic trains, patterned or random stimulation) and the storage model, the vesicular release, the replenishment of various vesicular pools, and the vesicular content of all pools could be simulated for the timeinvariant and time-varying storage systems. From the input stimuli and either a noiseless or a noisy output, the parameters of such storage systems could also be estimated using the optimization technique that minimizes in the least square sense the error between the observed release and the predicted release. All parameters of the storage model could be evaluated with sufficiently long input

• Type: Journal
• Year: 2004
• Where: BC
• Authors: F. Aristizabal, M. I. Glavinovic
• Keywords: BC 2004, Parameters, Vesicular, Vesicular Pools