Ever-changing production campaigns complicate the management of recovery and treatment options for unavoidable effluents at pharmaceutical plants. Each campaign produces large amounts of by-products differing in their number, amount as well as composition. Future business strategies designed to address changing market demands add uncertainty to this already challenging design problem. In such a dynamic and uncertain environment, the selection of operating policies as well as decisions to support future business operations by plant investments such as new reactors and separators is a formidable task. This paper will propose a systematic methodology for long-range, site-wide management strategies for batch manufacturing sites. Rigorous modeling of future regulatory changes will allow decision-makers to anticipate the monetary, infrastructural and ecological impact such new legislation may have on their businesses at a specific sites or an entire regions. The methodology will be illustra...
Aninda Chakraborty, Andres Malcolm, Richard D. Col