The increasing amount and complexity of data in toxicity prediction calls for new approaches based on hybrid intelligent methods for mining the data. This focus is required even more in the context of increasing number of different classifiers applied in toxicity prediction. Consequently, there exist a need to develop tools to integrate various approaches. The goal of this research is to apply neuro-fuzzy networks to provide an improvement in combining the results of five classifiers applied in toxicity of pesticides. Nevertheless, fuzzy rules extracted from the trained developed networks can be used to perform useful comparisons between the performances of the involved classifiers. Our results suggest that the neuro-fuzzy approach of combining classifiers has the potential to significantly improve common classification methods for the use in toxicity of pesticides characterization, and knowledge discovery.