Relaxation Oscillations in a Class of Delay Differential Equations

We study a class of delay differential equations which have been used to model hematological stem cell regulation and dynamics. Under certain circumstances the model exhibits self-sustained oscillations, with periods which can be significantly longer than the basic cell cycle time. We show that the long periods in the oscillations occur when the cell generation rate is small, and we provide an asymptotic analysis of the model in this case. This analysis bears a close resemblance to the analysis of relaxation oscillators (such as the Van der Pol oscillator), except that in our case the slow manifold is infinite dimensional. Despite this, a fairly complete analysis of the problem is possible. Key words. relaxation oscillations, delay differential equations, hematopoiesis, stem cells, chronic myelogenous leukaemia AMS subject classifications. 34K99, 92A07, 34C15, 34E05 PII. S0036139901393512

• Type: Journal
• Year: 2002
• Where: SIAMAM
• Authors: A. C. Fowler, Michael C. Mackey
• Keywords: Hematological Stem Cell, Oscillations, SIAMAM 2002, Van Der Pol Oscillator