The Center for Simulating Dynamic Response of Materials at the California Institute of Technology is constructing a virtual shock physics facility for studying the response of various target materials to very strong shocks. The Virtual Test Facility (VTF) is an end-to-end, fully three-dimensional simulation of the detonation of high explosives (HE), shock wave propagation, solid material response to pressure loading, and compressible turbulence. The VTF largely consists of a parallel fluid solver and a parallel solid mechanics package that are coupled together by the exchange of boundary data. The Eulerian fluid code and Lagrangian solid mechanics model interact via a novel approach based on level sets. The two main computational packages are integrated through the use of Pyre, a problem solving environment written in the Python scripting language. Pyre allows application developers to interchange various computational models and solver packages without recompiling code, and it provide...