Navigation and Exploration of Interconnected Pathways

Visualizing pathways, i. e. models of cellular functional networks, is a challenging task in computer assisted biomedicine. Pathways are represented as large collections of interwoven graphs, with complex structures present in both the individual graphs and their interconnections. This situation requires the development of novel visualization techniques to allow efficient visual exploration. We present the Caleydo framework, which incorporates a number of approaches to handle such pathways. Navigation in the network of pathways is facilitated by a hierarchical approach which dynamically selects a working set of individual pathways for closer inspection. These pathways are interactively rendered together with visual interconnections in a 2.5D view using graphics hardware acceleration. The layout of individual graphs is not computed automatically, but taken from the KEGG and BioCarta databases, which use layouts that life scientists are familiar with. Therefore they encode essential met...

• Type: Journal
• Year: 2008
• Where: CGF
• Authors: Marc Streit, Michael Kalkusch, Karl Kashofer, Dieter Schmalstieg
• Keywords: Cellular Functional Networks, CGF 2008, Individual Graphs, Individual Pathways