SuperHapten: a comprehensive database for small immunogenic compounds

The immune system protects organisms from foreign proteins, peptide epitopes and a multitude of chemical compounds. Among these, haptens are small molecules, eliciting an immune response when conjugated with carrier molecules. Known haptens are xenobiotics or natural compounds, which can induce a number of autoimmune diseases like contact dermatitis or asthma. Furthermore, haptens are utilized in the development of biosensors, immunomodulators and new vaccines. Although hapteninduced allergies account for 6–10% of all adverse drug effects, the understanding of the correlation between structural and haptenic properties is rather fragmentary. We have developed a manually curated hapten database, SuperHapten, integrating information from literature and web resources. The current version of the database compiles 2D/3D structures, physicochemical properties and references for about 7500 haptens and 25,000 synonyms. The commercial availability is documented for about 6300 haptens and 450 ...

• Type: Journal
• Year: 2007
• Where: NAR
• Authors: Stefan Günther, Dorothea Hempel, Mathias Dunkel, Kristian Rother, Robert Preissner
• Keywords: Adverse Drug Effects, Haptens, NAR 2007, Natural Compounds