Abstract As more and more life science researchers start to take advantages of grid technologies in their work, the demand increases for a robust yet easy to use metascheduler or resource broker. In this paper, we have extended the metascheduler CSF4 by providing a Virtual Job Model (VJM) to synchronize the resource co-allocation for cross-domain parallel jobs. The VJM eliminates dead-locks and improves resource usage for multi-cluster parallel applications compiled with MPICH-G2. Taking