Identification of Protein Coding Regions Using the Modified Gabor-Wavelet Transform

An important topic in genomic sequence analysis is the identification of protein coding regions. In this context, several coding DNA model-independent methods based on the occurrence of specific patterns of nucleotides at coding regions have been proposed. Nonetheless, these methods have not been completely suitable due to their dependence on an empirically predefined window length required for a local analysis of a DNA region. We introduce a method based on a modified Gabor-wavelet transform (MGWT) for the identification of protein coding regions. This novel transform is tuned to analyze periodic signal components and presents the advantage of being independent of the window length. We compared the performance of the MGWT with other methods by using eukaryote data sets. The results show that MGWT outperforms all assessed model-independent methods with respect to identification accuracy. These results indicate that the source of at least part of the identification errors produced by th...

• Type: Journal
• Year: 2008
• Where: TCBB
• Authors: Jesus P. Mena-Chalco, Helaine Carrer, Yossi Zana, Roberto M. Cesar
• Keywords: DNA Model-independent Methods, Model-independent Methods, TCBB 2008, Window Length