—In Multi-User MIMO networks, receivers decode multiple concurrent signals using Successive Interference Cancellation (SIC). With SIC a weak target signal can be deciphered in the presence of stronger interfering signals. However, this is only feasible if each strong interfering signal satisfies a signal-to-noiseplus-interference ratio (SINR) requirement. This necessitates the appropriate selection of a subset of links that can be concurrently active in each receiver’s neighborhood; in other words, a subtopology consisting of links that can be simultaneously active in the network is to be formed. If the selected sub-topologies are of small size, the delay between the transmission opportunities on a link increases. Thus, care should be taken to form a limited number of sub-topologies. We find that the problem of constructing the minimum number of sub-topologies such that SIC decoding is successful with a desired probability threshold, is NP-hard. Given this, we propose MUSIC, a fr...