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JOCN
2010

Prefrontal Control of Familiarity and Recollection in Working Memory

13 years 9 months ago
Prefrontal Control of Familiarity and Recollection in Working Memory
■ Left inferior frontal gyrus (IFG) is a critical neural substrate for the resolution of proactive interference (PI) in working memory. We hypothesized that left IFG achieves this by controlling the influence of familiarity- versus recollection-based information about memory probes. Consistent with this idea, we observed evidence for an early (200 msec)-peaking signal corresponding to memory probe familiarity and a late (500 msec)-resolving signal corresponding to full accrual of trial-related contextual (“recollectionbased”) information. Next, we applied brief trains of repetitive transcranial magnetic stimulation (rTMS) time locked to these mnemonicsignals,toleftIFGandtoacontrolregion.OnlyearlyrTMS of left IFG produced a modulation of the false alarm rate for high-PI probes. Additionally, the magnitude of this effect was predicted by individual differences in susceptibility to PI. These results suggest that left IFG-based control may bias the influence of familiarityand recoll...
Eva Feredoes, Bradley R. Postle
Added 28 Jan 2011
Updated 28 Jan 2011
Type Journal
Year 2010
Where JOCN
Authors Eva Feredoes, Bradley R. Postle
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