Complex networks, such as biological, social, and communication networks, often entail uncertainty, and thus, can be modeled as probabilistic graphs. Similar to the problem of similarity search in standard graphs, a fundamental problem for probabilistic graphs is to efficiently answer k-nearest neighbor queries (k-NN), which is the problem of computing the k closest nodes to some specific node. In this paper we introduce a framework for processing k-NN queries in probabilistic graphs. We propose novel distance functions that extend well-known graph concepts, such as shortest paths. In order to compute them in probabilistic graphs, we design algorithms based on sampling. During k-NN query processing we efficiently prune the search space using novel techniques. Our experiments indicate that our distance functions outperform previously used alternatives in identifying true neighbors in real-world biological data. We also demonstrate that our algorithms scale for graphs with tens of mill...