This article reports the results of a scientometric assessment of the Southern Africa Development Community countries. The National Science Indicators database of Thomson- Reuters and the online ISI Web of Knowledge are utilized in order to identify the number of publications of the 15 countries over a period of 15 years; the activity and relative impact indicators of 22 scientific disciplines for each country and their collaborative patterns. It is identified that South Africa with 19% of the population in the region is responsible for 60% of the regional GDP and 79% of the regions publications. All countries tend to have the same focus in their disciplinary priorities and underemphasize disciplines such as engineering, materials science and molecular biology. It is expressed concern that the current research infrastructures are inadequate to assist in reaching the objectives developed in the Regional Indicative Strategic Development Plan of the community.