—3GPP LTE has become a hot topic in recent years. One of its main challenges is the computationally intense task of MIMO detection. This paper investigates MIMO detection methods based on Sphere detection for 3GPP LTE system. A 3GPP LTE simulation chain has been developed for the evaluation. The results show that TS algorithm in combination with complexity reduction techniques of SSD and ME achieves a good tradeoff between performance and complexity for three different user scenarios. Furthermore, the results show the performance improvement achieved with SISO detection at low complexity. To the best of our knowledge, this is the first reported work about SISO detection for 3GPP LTE.