—In this paper, we present an interference model for cognitive radio (CR) networks employing power control or contention control scheme. The probability density functions (PDFs) of the interference received at a primary receiver from a CR network are derived for two cases. For the first case, a power control scheme is proposed to govern the transmission power of a CR node. For the second one, a cognitive media access control (MAC) employs carrier sense multiple access with collision avoidance (CSMA/CA) based contention control to coordinate the operation of CR nodes with transmission requests. These two control schemes are compared in terms of their resulting interference distributions. It is demonstrated that both power and contention controls are effective approaches to alleviate the interference caused by CR networks. Some in-depth analysis for the impact of key parameters on the interference of CR networks is given via numerical studies as well.