Real-time pattern classification of electromyogram (EMG) signals is significant and useful for developing prosthetic limbs. However, the existing approaches are not practical enough because of several limitations in their usage, such as the large amount of data required to train the classifier. Here, we introduce a method employing a selective desensitization neural network (SDNN) to solve this problem. The proposed approach can train the EMG classifier to perform various hand movements by using a few data samples, which provides a highly practical method for real-time EMG pattern classification. Key words: EMG Pattern Classification, Selective Desensitization Neural Network, Prosthetic Limb, Hand Movement Classification