The paper describes an experimental work conducted within the HILAS (Human Integration into the Lifecycle of Aviation Systemshttp://www.hilas.info/mambo/) project. The objective of HILAS is to develop a model of good practices for the Human Factors (HF) integration throughout the life-cycle of aviation systems. The project developed a toolkit of HF tools for the evaluation of new technologies for the flight deck. CRIA (Critical Interaction Analysis) is one of the HF tools included in HILAS toolkit. This paper reports the results of a real time simulation, held at NLR in Grace Simulator, where CRIA was applied to assess the HF issues implied in the replacement within the flight deck of the current radio panel with an Interseat Touch Screen (ITS), implemented by GE Aviation.