Customised Cytoarchitectonic Probability Maps Using Deformable Registration: Primary Auditory Cortex

A novel method is presented for creating a probability map from histologically defined cytoarchitectonic data, customised for the anatomy of individual fMRI volunteers. Postmortem structural and cytoarchitectonic information from a published dataset is combined with high resolution structural MR images using deformable registration of a region of interest. In this paper, we have targeted the three sub-areas of the primary auditory cortex (located on Heschl's gyrus), however the method could be applied to any other cytoarchitectonic region. The resulting probability maps show a significantly higher overlap than previous versions generated using the same cytoarchitectonic data, and more accurately span the macroanatomical structure of the auditory cortex. This improvement indicates a high potential for spatially accurate fMRI analysis, allowing more reliable correlation between anatomical structure and function. We validate the approach using fMRI data from nine individuals, taken f...

• Type: Conference
• Year: 2007
• Where: MICCAI
• Authors: Lara Bailey, Purang Abolmaesumi, Julian Tam, Patricia Morosan, Rhodri Cusack, Katrin Amunts, Ingrid S. Johnsrude
• Keywords: Accurate FMRI Analysis, Individual FMRI Volunteers, Medical Imaging, MICCAI 2007, Primary Auditory Cortex