In time-varying wireless networks, the states of the communication channels are subject to random variations, and hence need to be estimated for efficient rate adaptation and scheduling. The estimation mechanism possesses inaccuracies that need to be tackled in a probabilistic framework. In this work, we study scheduling with rate adaptation in single-hop queueing networks under two levels of channel uncertainty: when the channel estimates are inaccurate but complete knowledge of the channel/estimator joint statistics is available at the scheduler; and when the knowledge of the joint statistics is incomplete. In the former case, we characterize the network stability region and show that a maximum-weight type scheduling policy is throughput-optimal. In the latter case, we propose a joint channel statistics learning - scheduling policy. With an associated trade-off in average packet delay and convergence time, the proposed policy has a stability region arbitrarily close to the stability ...