Shape representation provides fundamental features for many applications in computer vision and it is known to be important cues for human vision. This paper presents an experimental study on recognition of mice behavior. We investigate the performance of the four shape recognition methods, namely Chain-Code, Curvature, Fourier descriptors and Zernike moments. These methods are applied to a real database that consists of four mice behaviors. Our experiments show that Zernike moments and Fourier descriptors provide the best results. To evaluate the noise tolerance, we corrupt each contour with different levels of noise. In this scenario, Fourier descriptor shows invariance to high levels of noise. Key words: Computer Vision, Shape Descriptors, Mice Behavior