Representing the Foundational Model of Anatomy (FMA) in OWL 2 is essential for semantic interoperability. The paper describes the method and tool used to formalize the FMA in OWL 2. One main strength of the approach is to leverage OWL 2 expressiveness and naming conventions of the native FMA to explicit some implicit semantics, meanwhile improving its ontological model and fixing some errors. A second originality is the flexible tool developed. It enables to easily generate a new version for each Protégé FMA update. While it provides one ‘standard’ FMA-OWL version by default, many options allow for producing other variants customized to users applications. To the best of our knowledge, no complete representation of the entire FMA in OWL DL or OWL 2 existed so far.