A large number of vision applications rely on matching keypoints across images. The last decade featured an arms-race towards faster and more robust keypoints and association algorithms: Scale Invariant Feature Transform (SIFT)[17], Speed-up Robust Feature (SURF)[4], and more recently Binary Robust Invariant Scalable Keypoints (BRISK)[16] to name a few. These days, the deployment of vision algorithms on smart phones and embedded devices with low memory and computation complexity has even upped the ante: the goal is to make descriptors faster to compute, more compact while remaining robust to scale, rotation and noise. To best address the current requirements, we propose a novel keypoint descriptor inspired by the human visual system and more precisely the retina, coined Fast Retina Keypoint (FREAK). A cascade of binary strings is computed by efficiently comparing image intensities over a retinal sampling pattern. Our experiments show that FREAKs are in general faster to compute with ...