Stackelberg security games have been widely deployed in recent years to schedule security resources. An assumption in most existing security game models is that one security resource assigned to a target only protects that target. However, in many important real-world security scenarios, when a resource is assigned to a target, it exhibits protection externalities: that is, it also protects other “neighbouring” targets. We investigate such Security Games with Protection Externalities (SPEs). First, we demonstrate that computing a strong Stackelberg equilibrium for an SPE is NP-hard, in contrast with traditional Stackelberg security games which can be solved in polynomial time. On the positive side, we propose a novel column generation based approach—CLASPE—to solve SPEs. CLASPE features the following novelties: 1) a novel mixed-integer linear programming formulation for the slave problem; 2) an extended greedy approach with a constant-factor approximation ratio to speed up the...