Quantitative Analysis of Myelin and Axonal Remodeling in the Uninjured Motor Network After Stroke

Contralesional brain connectivity plasticity was previously reported after stroke. This study aims at disentangling the biological mechanisms underlying connectivity plasticity in the uninjured motor network after an ischemic lesion. In particular, we measured generalized fractional anisotropy (GFA) and magnetization transfer ratio (MTR) to assess whether poststroke connectivity remodeling depends on axonal and/or myelin changes. Diffusion-spectrum imaging and magnetization transfer MRI at 3T were performed in 10 patients in acute phase, at 1 and 6 months after stroke, which was affecting motor cortical and/or subcortical areas. Ten age- and gendermatched healthy volunteers were scanned 1 month apart for longitudinal comparison. Clinical assessment was also performed in patients prior to magnetic resonance imaging (MRI). In the contralesional hemisphere, average measures and tract-based quantitative analysis of GFA and MTR were performed to assess axonal integrity and myelination alon...

• Type: Journal
• Year: 2015
• Where: BRAIN
• Authors: Ying-Chia Lin, Alessandro Daducci, Djalel Eddine Meskaldji, Jean-Philippe Thiran, Patrik Michel, Reto Meuli, Gunnar Krueger, Gloria Menegaz, Cristina Granziera
• Keywords: BRAIN 2015, Information Technology