We outline strategies for actuated tangible user interfaces (TUIs) to improve the study of proteins. Current protein study tools miss fundamental biology concepts because graphical and symbolic interfaces do not allow users to intuitively manipulate complex physical forms. Actuated, tangible tools may enhance understanding at all levels of protein study. To advance TUI awareness of protein study, we present an overview of protein concepts and current protein study tools. Thirty-six protein researchers, engineers, professors and students recommend design guidelines for tangible interfaces in protein study, and we outline research directions for TUIs to improve protein study at all educational levels. Keywords Tangible User Interface, Education, Biology, Actuation ACM Classification Keywords H.5.2: Information Interfaces and Presentation: User Interfaces. J.3 Life and Medical Sciences. K.3.1 Computer Uses in Education.