The Renaissance ideal can be expressed as a creative synthesis between cultural disciplines, standing in stark contrast to our traditional focus on scientific specialization. This panel presents a number of experts who approach the synthesis of art and science as the modus operandi for their work, using it as a tool for creativity, research, and practice. Understanding these approaches allows us to identify the roles of synthesis in successful innovation and improve the implementation of interdisciplinary synthesis in research and practice. Keywords Hybrid Practices, Management, Innovation, Design, Art, Creative synthesis, Creativity, Interdisciplinary Work. ACM Classification Keywords H5.m. Information interfaces and presentation