Learning Interpretable SVMs for Biological Sequence Classification

Background: Support Vector Machines (SVMs) ? using a variety of string kernels ? have been successfully applied to biological sequence classification problems. While SVMs achieve high classification accuracy they lack interpretability. In many applications, it does not suffice that an algorithm just detects a biological signal in the sequence, but it should also provide means to interpret its solution in order to gain biological insight. Results: We propose novel and efficient algorithms for solving the so-called Support Vector Multiple Kernel Learning problem. The developed techniques can be used to understand the obtained support vector decision function in order to extract biologically relevant knowledge about the sequence analysis problem at hand. We apply the proposed methods to the task of acceptor splice site prediction and to the problem of recognizing alternatively spliced exons. Our algorithms compute sparse weightings of substring locations, highlighting which parts of the ...

• Type: Conference
• Year: 2005
• Where: RECOMB
• Authors: Christin Schäfer, Gunnar Rätsch, Sören Sonnenburg
• Keywords: Computational Biology, Position Weight Matrices, RECOMB 2005, Support Vector, Support Vector Machines