Combining phylogenetic and hidden Markov models in biosequence analysis

A few models have appeared in recent years that consider not only the way substitutions occur through evolutionary history at each site of a genome, but also the way the process changes from one site to the next. These models combine phylogenetic models of molecular evolution, which apply to individual sites, and hidden Markov models, which allow for changes from site to site. Besides improving the realism of ordinary phylogenetic models, they are potentially very powerful tools for inference and prediction--for example, for gene finding or prediction of secondary structure. In this paper, we review progress on combined phylogenetic and hidden Markov models and present some extensions to previous work. Our main result is a simple and efficient method for accommodating higher-order states in the HMM, which allows for context-dependent models of substitution--that is, models that consider the effects of neighboring bases on the pattern of substitution. We present experimental results in...

• Type: Conference
• Year: 2003
• Where: RECOMB
• Authors: Adam C. Siepel, David Haussler
• Keywords: Computational Biology, Hidden Markov Models, Multiple Functional Categories, Phylogenetic Models, RECOMB 2003