A Statistical Model of Right Ventricle in Tetralogy of Fallot for Prediction of Remodelling and Therapy Planning

Tetralogy of Fallot (ToF) is a severe congenital heart disease that mainly affects the right ventricle (RV). It requires surgical repair early in infancy. Chronic regurgitations may appear due to damaged pulmonary valves, resulting in extreme RV dilation. To reduce risk factors late after repair, new pulmonary valves must be re-implanted. However, establishing the best timing for re-intervention is a clinical challenge because of the large variability in RV shape and in pathology evolution. The purpose of this study is to quantify the regional impacts of growth and regurgitations on the end-diastolic RV anatomy. The ultimate goal is to determine, among clinical variables, predictors for the shape in order to build a statistical model that predicts RV remodelling. The proposed approach relies on a forward model based on currents and LDDMM algorithm to estimate an unbiased template of 18 patients and the deformations towards each individual shape. Then, cross-sectional multivariate analy...

• Type: Conference
• Year: 2009
• Where: MICCAI
• Authors: Tommaso Mansi, Stanley Durrleman, Boris Bernhardt, Maxime Sermesant, Hervé Delingette, Ingmar Voigt, Philipp Lurz, Andrew M. Taylor, Julie Blanc, Younes Boudjemline, Xavier Pennec, Nicholas Ayache
• Keywords: End-diastolic Rv Anatomy, Extreme Rv Dilation, Medical Imaging, MICCAI 2009, RV Shape