Multi-class classification schemes typically require human input in the form of precise category names or numbers for each example to be annotated – providing this can be impractical for the user when a large (and possibly unknown) number of categories are present. In this paper, we propose a multi-class active learning model that requires only binary (yes/no type) feedback from the user. For instance, given two images the user only has to say whether they belong to the same class or not. We first show the interactive benefits of such a scheme with user experiments. We then propose a Value of Information (VOI)-based active selection algorithm in the binary feedback model. The algorithm iteratively selects image pairs for annotation so as to maximize accuracy, while also minimizing user annotation effort. To our knowledge, this is the first multi-class active learning approach that requires only yes/no inputs. Experiments show that the proposed method can substantially minimize u...