- The increase in autism prevalence has been the motivation for much research which has produced various theories for its causation. Genetic and environmental factors have been investigated. An area of focus is the affect of exposure to neurotoxins, such as mercury and lead, during critical stages in a child’s early development. In this study we apply Combinatorial Fusion Analysis (CFA) and Association Rule Mining (ARM) to autism prevalence, mercury, and lead data to generate hypotheses and explore possible associations. Keywords- Combinatorial Fusion Analysis (CFA), Rank-Score Characteristic (RSC) graph, Multiple Scoring Systems, Information Fusion, Association Rule Mining, Data Mining, autism, neurotoxins, lead, mercury