Functional coherence in domain interaction networks

Motivation: Extracting functional information from protein–protein interactions (PPI) poses significant challenges arising from the noisy, incomplete, generic and static nature of data obtained from high-throughput screening. Typical proteins are composed of multiple domains, often regarded as their primary functional and structural units. Motivated by these considerations, domain– domain interactions (DDI) for network-based analyses have received significant recent attention. This article performs a formal comparative investigation of the relationship between functional coherence and topological proximity in PPI and DDI networks. Our investigation provides the necessary basis for continued and focused ation of DDIs as abstractions for functional characterization and modularization of networks. Results: We investigate the problem of assessing the functional coherence of two biomolecules (or segments thereof) in a formal framework. We establish essential attributes of admissible ...

• Type: Conference
• Year: 2008
• Where: ECCB
• Authors: Jayesh Pandey, Mehmet Koyutürk, Shankar Subramaniam, Ananth Grama
• Keywords: Biology, ECCB 2008, Functional Coherence, Functional Similarity, Functional Similarity Measure