— In this paper, we propose multiuser multiple-input multiple-ouput (MIMO) one- and two-way relaying protocols. Several wireless MIMO node pairs are establishing either unidirectional or bidirectional transmission links via a single decodeand-forward MIMO relay without causing interference to each other. For both half-duplex two-phase relaying protocols, the relay separates messages of different node pairs spatially by using zero-forcing based methods, whereas, in order to cancel the interference within the bidirectional links, XOR precoding followed by self-interference cancellation is employed. Both sum rate and maxmin fairness optimizations, as well as quality-ofservice assurance, are considered for the design of the precoders at the relay. The corresponding optimization algorithms for both one- and two-way relaying have been developed using semidefinite programming, which consider the intersection of multiple access and broadcast phases’ rate regions.