This paper focuses on developing a haptic rendering technique for cellular manipulation using image processing techniques and physically based models. The interaction forces between a micropipette and cellular tissues are predicted based on biomechanical models of cells, which consist of a boundary element model and a prior knowledge of the cell’s mechanical properties. These models are used to allow users to feel amplified reaction forces during cell injection tasks through a haptic device in real time. The experimental system, equipped with a micro-injection system and a commercial haptic display, was developed and tested using zebrafish embryos. The proposed haptic rendering algorithm could be used to improve success rates of cellular manipulation tasks.