—In this contribution an accurate average bit error rate (BER) formula is derived for Nakagami-faded MC-DSCDMA in the context of asynchronous transmissions and random spreading sequences. Our analysis is based on the Characteristic Function (CF) and does not rely on any assumption concerning the statistical behavior of the interference. We develop a new closed-form expression for the conditional CF of the inter-carrier interference and provide a procedure for calculating the exact BER expressed in the form of a single numerical integration. The accuracy of the standard Gaussian approximation (SGA) technique is also evaluated. Link-level results confirm the accuracy of the SGA for most practical conditions.