Clustering large data sets with high dimensionality is a challenging data-mining task. This paper presents a framework to perform such a task efficiently. It is based on the notion of data space reduction, which finds high density areas, or dense cells, in the given feature space. The dense cells store summarized information of the data. A designated partitioning or hierarchical clustering algorithm can be used as the second step to find clusters based on the data summaries. Using Kmeans as an example, this paper presents GARDEN-Kmeans, which performs data space reduction using Gamma Region DENsity partition, and utilizes Kmeans to cluster the summarized information. The experimental study shows that GARDEN-Kmeans executes several orders of magnitude faster than basic Kmeans and the recursive bisection Kmeans algorithm of CLUTO, while producing comparable clustering quality.