Clinical decision-making involves an active interplay between various medical knowledge modalities. Medical knowledge morphing aims to support clinical decision support by mimicking the interplay between knowledge modalities, as per the problem description, to derive a holistic knowledge-base. We leverage the Semantic Web technology suite to pursue knowledge morphing. We present a Knowledge Morphing framework that involves ontologies to represent the domain and knowledge artifacts, annotation of knowledge artifacts based on the respective ontological model, and ontology mediation activities to knowledge morphing.